Journal:

Article Title: Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats

doi: 10.1038/sj.bjp.0704354

Figure Lengend Snippet: Effect of intrathecal injections of a non-competitive NMDA receptor antagonist, MK-801 (0.6, 6.0, 60 nmol rat−1, n=8/dose) or saline (10 μl rat−1, n=8) on the time-course of the vocalization threshold of Mg-deficient rats submitted to the paw pressure test (A). AUC was calculated throughout the period of 120 min for each dose in Mg-deficient rats (B). Results are expressed as means±s.e.mean. *P<0.05, **P<0.01 and ***P<0.001; compared to the saline-treated group of Mg-deficient rats.

Article Snippet: Two competitive NMDA receptor antagonists: D -2-amino-5-phosphono-valeric acid (AP-5) binding to the glutamate site (ICN Pharmaceuticals France, Orsay, France), was dissolved in saline and 5,7-dichlorokynurenic acid (DCKA) binding to the glycine site (RBI, Sigma-Aldrich Co., Saint Quentin Fallavier, France), was dissolved in 50% dimethyl sulphoxide (DMSO, Sigma-Aldrich Co., Saint Quentin Fallavier, France) (vehicle).

Techniques: Saline, Randall–Selitto Test

Journal:

Article Title: Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats

doi: 10.1038/sj.bjp.0704354

Figure Lengend Snippet: Effect of intrathecal injections of two competitive NMDA receptor antagonists, AP5 (10.2, 40.6, 162.3 nmol rat−1, n=8/dose) or saline (10 μl rat−1, n=8) (A) and DCKA, (0.97, 9.7, 97 nmol rat−1, n=7/dose) or vehicle (10 μl rat−1, n=7) (C) on the time-course of the vocalization threshold of Mg-deficient and control rats submitted to the paw pressure test. AUC was calculated throughout the period of 120 min for each dose in Mg-deficient and control rats (B,D). Results are expressed as means±s.e.mean. *P<0.05, **P<0.01 and ***P<0.001; compared to the saline or vehicle-treated groups of Mg-deficient rats.

Article Snippet: Two competitive NMDA receptor antagonists: D -2-amino-5-phosphono-valeric acid (AP-5) binding to the glutamate site (ICN Pharmaceuticals France, Orsay, France), was dissolved in saline and 5,7-dichlorokynurenic acid (DCKA) binding to the glycine site (RBI, Sigma-Aldrich Co., Saint Quentin Fallavier, France), was dissolved in 50% dimethyl sulphoxide (DMSO, Sigma-Aldrich Co., Saint Quentin Fallavier, France) (vehicle).

Techniques: Saline, Control, Randall–Selitto Test